Thanks Joseph. I wonder if etiocholan-3α-ol-17-one sulfate is a marker found in other chronic pain conditions or if it's unique to IC/PBS? I hope they explore if it's a possible contributing cause of symptoms OR the result of having the condition. I know there are other chronic conditions that share symptoms with IC/PBS. I've often thought these shared systemic symptoms are the body's response to on-going pain, stress and distress, rather than the disease itself.