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 Alterations of microbiota in urine from women with interstitial cystitis (U.K. Biomed Central Study)

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joseph_abney34



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Join date : 2016-01-31

PostSubject: Alterations of microbiota in urine from women with interstitial cystitis (U.K. Biomed Central Study)   Wed Apr 06, 2016 8:01 am

I will post the background, results, and conclusion of this study done in the U.K. It was conducted in 2012 and is very interesting.

Background
Interstitial Cystitis (IC) is a chronic inflammatory condition of the bladder with unknown etiology. The aim of this study was to characterize the microbial community present in the urine from IC female patients by 454 high throughput sequencing of the 16S variable regions V1V2 and V6. The taxonomical composition, richness and diversity of the IC microbiota were determined and compared to the microbial profile of asymptomatic healthy female (HF) urine.

Results
The composition and distribution of bacterial sequences differed between the urine microbiota of IC patients and HFs. Reduced sequence richness and diversity were found in IC patient urine, and a significant difference in the community structure of IC urine in relation to HF urine was observed. More than 90% of the IC sequence reads were identified as belonging to the bacterial genus Lactobacillus, a marked increase compared to 60% in HF urine.

Conclusion
The 16S rDNA sequence data demonstrates a shift in the composition of the bacterial community in IC urine. The reduced microbial diversity and richness is accompanied by a higher abundance of the bacterial genus Lactobacillus, compared to HF urine. This study demonstrates that high throughput sequencing analysis of urine microbiota in IC patients is a powerful tool towards a better understanding of this enigmatic disease.

Here is a link http://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-12-205

Basically there is a higher amount of this thing called Lactobacillus and lower diversity in other microbes that were in healthy women. Hopefully more research uncovers why this is. Anyway wanted to make everyone aware of this study. IC will be cured someday. Its only a matter of time once they figure out all the workings of this enigmatic disease.
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Strandsidemol



Posts : 64
Join date : 2016-02-15
Age : 39
Location : Leicestershire,uk

PostSubject: Re: Alterations of microbiota in urine from women with interstitial cystitis (U.K. Biomed Central Study)   Wed Apr 06, 2016 1:48 pm

Very intetesting, whats that mean we are over run by friendly bacteria they turned pathogenic on us/each other causing our symptoms. There is defintely a reason why we got so unbalanced though. Have you seen the pathogenus reports on another thread, there are only a few coming through showing lactobacillus.
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