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 Understanding the Pathogens Responsible for Recurrent Urinary Tract Infections in Postmenopausal Women

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Andi2016

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Join date : 2016-01-07

PostSubject: Understanding the Pathogens Responsible for Recurrent Urinary Tract Infections in Postmenopausal Women    Sun Mar 25, 2018 3:18 pm

It looks like more and more research teams are looking into the connection between intracellular bacterial communities (IBC) and urinary conditions like recurrent UTIs.  IBC can't be detected using standard UTI testing.  This is another US team.

https://www.urotoday.com/conference-highlights/102375-sufu-2018-understanding-the-pathogens-responsible-for-recurrent-urinary-tract-infections-in-postmenopausal-women.html


'Understanding the Pathogens Responsible for Recurrent Urinary Tract Infections in Postmenopausal Women'

"Austin, TX (UroToday.com) The work with murine models has shown that uropathogenic Escherichia coli (UPEC) is able to invade the bladder urothelium and form intracellular reservoirs. Dr. Nicole De Nisco and colleagues analyzed a cohort of postmenopausal women undergoing cystoscopy with fulguration of trigonitis (CFT) for treatment of RUTI after multiple failed antibiotic courses.  

"They had bladder biopsies and urine from women meeting study criteria for antibiotic-refractory RUTIs and with office-based evidence of chronic cystitis on flexible cystoscopy. All samples were obtained in the operating room under anesthesia following a rigorous protocol. Antibiotics were discontinued for at least one week prior to CFT. Tissue and urine samples were analyzed using both culture-based and molecular approaches to determine if intracellular bacterial reservoirs are present within the bladder urothelium. The methods included aseptic microbial culture, 16S rRNA fluorescence in situ hybridization, 16S rRNA variable (v4) region Illumina deep sequencing, as well as basic molecular biology and histological techniques.

"They showed these preliminary studies of six post-menopausal RUTI patients with extensive cystitis cystica or pancystitis indicated that a variety of Gram-negative and Gram-positive bacteria were present inside the bladder urothelium. Strikingly, negative urine cultures at the time of CFT were noted in some patients despite positive bacterial tissue sample findings.

"In conclusion they have found that diverse and unexpected bacterial species can invade the urothelium of severely infected post-menopausal RUTI patients. These intracellular bacterial reservoirs may explain the observed cycles of recurrence."
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