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 The Female Microbiota, Urinary Health and Common Urinary Disorders (Braubaker and Wolfe)

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PostSubject: The Female Microbiota, Urinary Health and Common Urinary Disorders (Braubaker and Wolfe)   Wed Feb 01, 2017 12:46 pm

Here's a new Review Article from Linda Braubaker and Alan Wolfe (Loyola University, Chicago), published in the 2017 Annals of Translational Medicine.


The Female Urinary Microbiota, Urinary Health and Common Urinary Disorders

The article says the female urinary microbiota (FUM) exists in the bladder and these microbes are NOT contaminants, contrary to what is currently believed by doctors and microbiologists.  Emerging evidence linking the characteristics and variability of these microbial communities in health, as well as dysbiosis, can not be ignored.   The FUM appears to be related to UTI and UUI in adult women, but the specific role of the FUM needs further research.  Clinicians should adopt advanced urine culture techniques to identify bacteria.

"This additional information may provide clinicians and their patients an opportunity to impact clinical care without antibiotic use, if the FUM can be appropriately modified to improve treatment precision for UTI and UUI."  

Concluding Comments:

"The recent confirmation that the FUM exists—that there is a resident community of bacteria in the adult bladder—challenges the scientific community to understand these microbiota in health and disease. This will require researchers to address basic questions about normal FUM characteristics: how does the FUM get established and maintained? What are the community characteristics of a healthy FUM? How stable is the FUM? Does it respond to diet and other behaviors? Is it resilient in the face of perturbations, such as antibiotics, instrumentation, surgery or other therapies? What roles do members of the FUM play? Which microbes are beneficial? Which ones are detrimental? Do unrecognized uropathogens lurk within the FUM? How do members of the FUM interact with the urothelium? Most importantly from a clinical perspective, it is important that we learn whether the urinary microbiota can be clinically modified to prevent lower urinary tract disorders, especially common conditions, such as UTI and UUI.
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